BCL 2 L 11 ( BCL 2 - like 11 ( apoptosis facilitator ) )
نویسندگان
چکیده
Other names: BAM, BIM, BIM-alpha6, BIM-beta6, BIM-beta7, BOD, BimEL, BimL HGNC (Hugo): BCL2L11 Location: 2q13 Local order: According to GeneLoc and NCBI Map Viewer, genes flanking BCL2L11 in plus strand direction are: ACOXL 2q13 (acyl-Coenzyme A oxidase-like); PAFAH1P2 2q13 (platelet-activating factor acetylhydrolase, isoform Ib, pseudogene 2). Note: BCL2L11/BIM is a BH3-only protein from the Bcl-2 family. Bcl-2 family members are the main regulators of programmed cell death via the mitochondrial (intrinsic) apoptotic pathway. Interactions between proand anti-apoptotic proteins of the Bcl-2 family decide the fate of cells after a stress signals. BH3-only proteins are activated in response to cellular stresses such as DNA damage. BCL2L11/BIM is one of the most potent BH3-only proteins, shown to mediate apoptosis in response to stimuli such as cytokine deprivation, deregulated calcium flux and microtubule perturbation. In vivo, BCL2L11/BIM is essential for hematopoietic homeostasis, thymocyte negative selection and as a barrier against autoimmunity.
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